Tooth Fairies Beware: Japan Begins Human Tests to Grow New Teeth — No Magic Wand Required!

TRG-035: Because Dentures Are So Last Century! Imagine a world where losing a tooth does not doom you to a lifetime of awkward smiles, crunchy corn avoidance, or nightly prayers to the Tooth Fairy for an inflation-adjusted payout. That future just edged closer: a Japanese research team launched the world’s first human clinical trials of TRG-035 , a drug designed to regrow human teeth by blocking a protein called USAG-1 , which normally tells budding teeth to “keep calm and stay dormant.” If you’ve been following the saga of regenerative dentistry from the periphery (or the ugliest nook of TikTok), here’s the non-sci-fi summary. USAG-1 is one of those biochemical hall monitors that prevents extra teeth from forming once your pearly set is supposedly complete. In lab animals — namely mice and ferrets — researchers found that blocking USAG-1 reactivated dormant tooth-forming stem cells, which then set about building fully functional teeth. Which is, objectively, both asto...